This is a list of animal species that have been extirpated, eliminated, and wiped out from extinction throughout the Appalachian National Parks or in the Appalachian Area. (Shenandoah Valley, Blue Ridge Mountains, Great Smoky Mountains)

Some of the animal species that have been eliminated or extirpated

- Bison:  around 1798

- elk: 1855

- Beaver: 1800's

- river otter: late 1800's

- timber wolf: 1912

- eastern cougar (mountain lions): around 1911 

- white-tailed deer: 1920's

- peregrine falcon: 1950's reintroduced back in the Great Smoky Mountains in the 1900s

- black bear: 1900's.  Back in the park thanks to conservation programs and protection from the Shenandoah Park. Reforested land.

Some of the animal species that have been extinct

- eastern sub-species of peregrine falcons: when pesticides made it harder for them to reproduce

- wolves

Animal species that have been extinct about 20,000 years ago

- ground sloth

- American Mastodon

- immense bison

- woolly mammoth

Ever since 1936 when the Appalachian Park was established, some of the animal species that were eliminated or extirpated have been reintroduced several years later back into the park by the help of the Park Management, or have even came back on its own.  Some of those animal species are the white-tailed deer and several turkeys that were reintroduced in 1934.  The beaver species were also reintroduced back into the park but are rare since their habitat is restricted in a small area.  The cougar also known as the mountion lion was seen in the park for several years from a few people but its "sightings have never been officially documented." Bobcats have also been reintroduced but today there is only a few of them and are hardly ever seen.